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KEYNOTE SPEAKER |
David R. Walt | Measuring Scientific Impact David R. Walt is the Hansjörg Wyss Professor of Bioinspired Engineering at Harvard Medical School and Professor of Pathology at Harvard Medical School and Brigham and Women’s Hospital, is a Core Faculty Member of the Wyss Institute at Harvard University, Associate Member at the Broad Institute, and is a Howard Hughes Medical Institute Professor. Dr. Walt is co-Director of the Mass General Brigham Center for COVID Innovation. Dr. Walt is the Scientific Founder of Illumina Inc., Quanterix Corp., and has co-founded several other life sciences startups including Ultivue, Inc., Arbor Biotechnologies, Sherlock Biosciences, and Vizgen, Inc. He has received numerous national and international awards and honors for his fundamental and applied work in the field of optical microwell arrays and single molecules. He is a member of the National Academy of Engineering, the National Academy of Medicine, a Fellow of the American Academy of Arts and Sciences, a Fellow of the American Institute for Medical and Biological Engineering, a Fellow of the American Association for the Advancement of Science, a Fellow of the National Academy of Inventors, and is inducted in the US National Inventors Hall of Fame. David pioneered the use of microwell arrays for single-molecule detection and analysis, which has revolutionized the process of genetic and proteomic sequencing, enabling the cost of DNA sequencing and genotyping to plummet nearly a millionfold in the last decade. This technology is now the gold standard for sequencing in a wide variety of applications including screening embryos for genetic defects before in vitro fertilization, studying disease in preserved/frozen tissues, improving crop disease resistance, and identifying individuals’ metabolic profiles to ensure proper drug dosage. David’s current research employs optical fiber microarrays for the detection and analysis of single enzyme molecules to provide mechanistic insight into enzyme mechanisms. In another project, his lab is investigating the limits of creating high-density sensing arrays containing thousands of microsensors and nanosensors, and are preparing arrays to perform high-density nucleic acid and protein analysis. One application of this effort is an integrated diagnostic platform for performing medical diagnostics using saliva as a sample instead of blood. The arrays can also be used to study living cells, both as cell populations and as individual cells, and analyze the contents of individual cells by integrating microfluidics with single-molecule detection. They are also studying the behavior of large numbers of cells to understand the distribution of cell behaviors in a population. |
SESSIONS AND PRESENTATIONS (SUBJECT TO CHANGE) AES ELECTROPHORESIS(21AES01) Lifetime Achievements Award Session - Chairs: Alexandra Ros, Juan Santiago Presentations and speakers coming soon. (21AES02) Electrokinetic Fundamentals - Chair: Christopher Harrison All presentations in this session will be chosen from contributed abstracts. (21AES03) Emerging Leaders in Electrophoresis - Chairs: Jason Dwyer, Nicole Hill Significant heterogeneity in stem cell populations useful for transplantation Tayloria Adams Thermal Gel Electrophoresis for Biological Analyses (21AES04) Electrophoretic Bioanalytical and Pharmaceutical Analyses - Chair: Erin Henslee Presentations and speakers coming soon.
ART & ARCHAEOLOGY(21ART01) Student Research in Archaeological Chemistry - Chair: Alex Bertacchi Modern Methods on Old Mandibles: New Analysis of Caprines from Tepe Yahya Interpreting geochemical data in archaeological context; a case for interdisciplinary methodology in paleoclimate and site formation research Removing the Unwanted: A Systematic Comparison of Decontaminating Protocols for Ancient Dental Calculus Research Establishing Provenience of a Miocene Fossil Collection from Kenya - A Standardless pXRF Method Proof of Concept Using concentrations of rare elements to detect diagenesis in archaeological hard tissues (21ART02) Archaeological, Geochemical, and Remote Sensing Applications in the Search for Pleistocene Landscapes of New England - Chair: David Leslie Presentation titles coming soon. Speakers:
ATOMIC SPECTROSCOPY(21ATOM01) Medical & Pharma - Chair: Uwe Karst One-year gadolinium retention in healthy rats after repeated injections of macrocyclic and linear contrast agents Sabrina Funke More presentations and speakers coming soon. (21ATOM02) Single Cell and Nanoparticle ICP-MS - Chairs: Heidi Goenaga-Infante, John Olesik Practical approaches for single particle analysis of nanoparticles in natural waters The application of single cell ICP-MS in microbiology: a world to explore Automated Single-Particle-ICP-TOFMS for Quantification and Classification of Nanoparticles in Environmental Samples Building A Robust Nanomaterial Measurement Infrastructure: Successes and Challenges
Sarah Meyer (21ATOM03) Laser Ablation - Chair: Todor Todorov Characterization of new float glass standards for use in forensic comparisons using laser ablation inductively coupled plasma mass spectrometry Isotope analysis of geologic materials by LA-MC-ICP-MS U-Pb age mapping of titanite by LA-ICP-MS Laser ablation inductively coupled plasma mass spectrometry exploration of metal solubilization from implanted pellets in rat tissues New ways of chemical imaging: combining species-specific solute sampling by diffusive gradients in thin films with high-resolution LA-ICP-MS analysis Stefan Wagner (21ATOM04) Unique Plasma-based Sources for Chemical/Isotopic Analysis - Chairs: C Derrick Quarles Jr., Benjamin Manard The LS-APGD/Orbitrap Coupling: Uranium Isotopic Analysis and Beyond Cold Atmospheric Micro Plasma: A Powerful Tool From Biomaterials to Biomedical Applications TBD Modulation of the solution-cathode glow-discharge and solution-anode glow-discharge using a rotating magnetic field Systematic investigation of fundamental parameters of μs-pulsed radiofrequency and direct current glow discharge under optical emission spectroscopy elemental mapping conditions via laser scattering Kevin Finch (21ATOM05) Atomic Spectrometry and the Impact of Ramon M. Barnes - Chairs: Gary M. Hieftje, R. Kenneth Marcus Ramon M. Barnes: Stalwart of Spectrochemistry All I really needed to know I learned…in graduate school Ramon Barnes: How a Sage of Atomic Spectroscopy Paved the Road Ahead The Winter Conference: An Enabling Technology for My Career in Academia San Diego 1992 to Tucson 2020 - a ride through (LA-)ICPMS
BIOMEDICAL & BIOANALYTICAL(21BIM01) Biophotonics Technologies Fighting Infections at the Point of Care - Chairs: Ute Neugebauer, Juergen Popp High-throughput imaging and deep learning for detecting blood clots in COVID-19 Planar Waveguide Biosensor for Point-of-Care Fluorescent Immunoassays Biophotonics light the way for SARS-CoV-2 diagnostics Biophotonic analysis of the immune response to enable rapid detection of infection (21BIM02) Translation of Multimodal Imaging Technologies into Clinical Routine - Chairs: Thomas Bocklitz, Anuradha Ramoji FLIM in the Operating Theater TBD TBD Raman spectroscopic imaging for clinical diagnostics (21BIM03) Vibrational Spectroscopy for Cancer Screening and Diagnostics - Chair: Fay Nicolson Pharmacokinetic Tomography: Mapping Drug Uptake in Tissue with Coherent Raman Imaging Estimating the depth of inclusion and the optical properties of biological tissues using Deep Raman Spectroscopy Nanoscale plasmonics for cancer lipid biopsy: practical aspects of detecting extracellular vesicles amidst the nano-junk (21BIM04) Nanotheranostics: Diagnosis and Treatment of Disease using Nanomaterials - Chair: Samuel Mabbott Deep Raman enabled search-(SERS)-ing of cancer tumour through >5 cm of animal tissue. Engineering the tumor microenvironment to improve immunotherapy SESORS for pre-clinical cancer imaging
CHEMOMETRICS(21CHEM01) Bringing it All Back Home: Data Integration Through Chemometrics - Chair: Federico Marini Presentations and speakers coming soon. (21CHEM02) Chemometric Theory in Practice - Chair: Karl Booksh Handling Noise in Portable Instrumentation Karl Booksh Variable Selection applied to Portable Instrumentation Application of Hand-Held Technologies and Chemometrics to Forensic Investigations in Illicit Narcotics Characterization of Chinese Celadon Ceramics by LIBS and XRF Analysis of Geological Sample Suites with Laser-induced Breakdown Spectroscopy Richard Hark (21CHEM03) Chemometric Opportunities in the Forensic Sciences - Chair: Brooke Kammrath Probabilistic Reporting of Glass Evidence Comparisons from Elemental Data Acquired by LA-ICP-MS Spatial Domain Forensic Applications of the Fourier Transform Data analysis strategies for the elemental analysis of tire evidence (21CHEM04) Chemometrics for Food and Drug Analysis - Chair: Mengliang Zhang TBD Machine Learning Enabled Nondestructive Paper Chromogenic Array Detection of Multiplexed Viable Pathogens on Food Detecting Seafood Decomposition with Portable Devices and Chemometric Modeling
CONTEMPORARY ISSUES IN ANALYTICAL SCIENCE & EARLY CAREER RESEARCHERS(21CTP/EARLY01) We, the Scientists: Strategies to Support Diversity, Equity, and Inclusion - Chair: Karen Esmonde-White Presentations and speakers coming soon.
MASS SPECTROMETRY(21MASS01) Rapid Hydrogen-Deuterium Exchange Mass Spectrometry for Structural and Mixture Analysis - Chair: Ian Webb Real World Applications of Sub-second HDX for Drug Development in Cancer and Neurodegenerative Disease TBD Local and Global HDX of Nascent Gas-Phase Protein Ions Standardizing gas-phase H/D exchange measurements across different platforms (21MASS02) Ionization in Mass Spectrometry: Fundamentals and New Applications - Chair: Kaveh Jorabchi Vibrating Sharp Edge Nebulization: New Interfacing for Capillary Electrophoresis and Mass Spectrometry Development of Novel Microwave-Assisted Techniques for Mass Spectrometry Absolute Quantitation of Peptides and Proteins by Coulometric Mass Spectrometry Enahnced Elemental Ionization for Quantitation Using Intrinsic Elemental Tags Ionization mechanisms of alkanes
MOLECULAR(21IR01) Nanoscale IR - Chair: Georg Ramer Infrared Nanospectroscopy at the Single Molecule Scale TBD Advanced AFM-IR Studies of Functional Nanomaterials: When Scanning Probe Microscopy Teams up with Vibrational Spectroscopy Analytical measurements of pristine interplanetary dust particles: What do we expect from AFMIR analysis? (21IR02) Advances in Photothermal Spectroscopy - Chairs: Rohith Reddy, Curtis Marcott Analysis of fixed and live single cells using optical photothermal infrared with concomitant Raman spectroscopy TBD (21IR03) Two-Dimensional Correlation Spectroscopy - Chair: Young Mee Jung Two-Dimensional Correlation Spectroscopy (2D-COS) Study of Bioplastics Ageing of dark and white bread: A 2DCOS analysis by handheld NIR spectroscopy Understanding Protein Dynamics using Quantum Cascade Laser Microscopy, 2DCOS and 2DCDS Temperature-perturbed IR and NIR measurements with combination of 2T2D correlation analysis for improving discrimination of diverse samples Understanding Microdomains and Molecular Level Mixing in Poly(hydroxyalkanoate) Bioplastic Blends and Laminates Using Simultaneously Collected Optical Photothermal Infrared and Raman Spectra (21IR04) Evanescent Wave Sensing: New Developments and Applications - Chair: Bernhard Lendl Presentations and speakers coming soon. (21IR05) Probing Orientation/Anisotropy by Infrared Spectroscopy - Chair: Takeshi Hasegawa Template-Free Orientation Control in Thin Films of Small-Molecule Organic Semiconductors Determination of the tilt angle of the axis of α-helix of specific residue of α-synuclein(61–95) in amphiphilic monolayer Infrared Spectroscopy Study of Self-Assembled Monolayers Micro ATR-FTIR imaging to analyze spatial distribution of molecular orientation in films Infrared spectroscopic polarimetry of anistropic thin films and structured surfaces
NASLIBS(21LIBS01) Deep Dive in LIBS Principle - Chair: Alessandro De Giacomo Artifacts in Laser-Ablation Absorption Spectroscopy
TBD (21LIBS02) Consolidation of LIBS Methodology - Chair: Noureddine Melikechi Getting LIBS results outside the laboratory: lessons from the field Application of Laser-Induced Breakdown spectroscopy in Environmental and Biological areas of Research LIBS Intelligence: autonomy and decision-making from spectral data. Auto-focus LIBS applications for the process control using long and short laser pulses Listening for rock coatings on Mars: Understanding acoustic signals from laser-induced breakdown spectroscopy (21LIBS03) LIBS Analytical Applications I - Chair: Christian Goueguel TBD TBD (21LIBS04) LIBS Analytical Applications II - Chair: Vassilia Zorba LIBS and acoustic frequency spectra correlated. Towards an improved strategy for rocks and minerals identification with the SuperCam instrument of the MARS 2020 rover 193nm-Excimer Tandem LIBS and LA-ICP-MS – the case of geological samples Tracing the provenance of minerals using advanced machine learning methods on LIBS spectra (21LIBS05) Microanalysis Using LIBS - Chair: Kheireddine Rifai Presentations and speakers coming soon. (21LIBS06) Innovation in LIBS Instrumentation - Chair: Rosalba Gaudiuso Nanomaterials, solid phase microextraction and LIBS: A synergistic association for the development of analytical methodologies easily integrable in portable systems LIBS, an open field of research for heritage science applications TBD
PHARMACEUTICAL ANALYSIS(21PMA01) Manufacturing of the Future: Innovative PAT Tools and Advanced Process Control - Chair: Claudia Corredor How healthy is your culture? Cell death detection using dielectric spectroscopy
Ensuring good analytical sampling by fiber optic probes inserted into moving powder beds
Smart PAT for development and manufacturing; inform, understand, monitor and optimise (21PMA02) Advanced Spectroscopy for Biopharmaceutical Characterisation: Using Multidimensional Fluorescence and Light Scattering Techniques for Protein Characterisation. - Chair: Alan Ryder In-line size determination of nanoparticulate biotherapeutics using spatially resolved dynamic light scattering
Delving Deeper Into AAV Attributes: Enhanced Characterization Using Multiple Technologies
Monitoring protein conjugation reactions for Antibody-Drug Conjugate (ADC) synthesis using polarized Excitation Emission Matrix (pEEM) spectroscopy (21PMA03) Innovating PAT in Bioprocessing - Chairs: Anja Mueller, Géraldine Baekelandt Microsecond resolved infrared spectroscopy on non-repetitive protein reactions by applying caged-compounds and quantum cascade laser frequency combs
PAT for Real-Time Monitoring of mRNA Production
Optical Spectroscopy for Biopharma Development and Manufacturing
(21PMA04) Structure Elucidation of Chiral and Biological Molecules - Chairs: Rina Dukor Dukor, Christian Johannessen Presentations and speakers coming soon. (21PMA05) Industrial Applications of Vibrational Spectroscopy - Chairs: Patrick Wray, Andrew Chan Development of a QbD based PAT for inline quantification of drugs in continuous manufacturing
Subcellular FTIR imaging with novel ZnS hemispheres for studying phospholipidosis in live macrophages
Vibrational Spectroscopy to Assess Degradation of Purification Resins used in the Downstream Processing of Monoclonal Antibodies.
(21PMA06) Small Molecule and Metabolic Screening - Chairs: Kat Hollywood, Roy Goodacre Triboelectric Nanogenerator Ion Mobility-Mass Spectrometry for In-Depth Lipid Annotation
Metab-endotyping as a route to precision medicine (21PMA07) End-to-end analytical development in Cell and Gene Therapy - Chair: Deniz Temel CMC and Analytic Challenges for cell-based therapies TBD Addressing the issues around low throughout testing for AAV characterization using SECMALS. To separate or not to separate? A simple IEX-UV approach for AAV Empty/Full capsid determination Product Characterization for Cell Therapies Yu Qian
PROCESS ANALYTICAL(21PAT01) PAT Biopharma - Chair: Edita Botonjic-Sehic Index of Refraction monitor as part of a PAT strategy for downstream processing Detection and Quantitation of Protein Aggregates by Microfluidic Modulation Spectroscopy Eugene Ma
(21PAT02) PAT Pharma/Biotech - Chair: Daniel Hill Spectroscopy-based sensors in Biopharmaceutical Manufacturing Application of Online UPLC in ASO Process Development and Manufacturing Improving Biologics Downstream Processes with Real-time Measurements In Situ Particle Size Measurements in Biologics Downstream Processing
(21PAT03) PAT for Industrial R&D - Chairs: Shawn Chen, Mark Rickard Indirect Water Measurement in Refined Acrolein Stream by Process Raman Spectroscopy Artificial Intelligence and Micro Spectral Sensors Technologies Shaping The Future of Spectroscopy Globally monitoring 9,000+ molecular groups in whole crude using spectroscopy (21PAT04) Advances in On-Line Process Analysis - Chair: Alison Nordon Thermal Infrared Hyperspectral Imaging for Gas Detection, Identification, and Quantification TBD
RAMAN(21RAM01) Emerging Raman Spectroscopy Breakthroughs - Chair: Pavel Matousek Noninvasive glucose monitoring using NIR Raman spectroscopy Raman spectroscopy and imaging of single cells in flow (21RAM02) SERS - Chair: Roy Goodacre SERS detection for bacterial identification and antibiotic testing Paper-based Diagnostics at the Point-of-Care Authentication of pharmaceuticals using SERS Nanostructured Probes for Virus Detection: Reducing Costs while Retaining Selectivity and Sensitivity
Spectroscopy at the point-of-care Bimolecular radiation response monitoring using Raman spectroscopy and data analytics Tuning, Torturing, and Touching Up a SERS Substrate (21RAM04) Clirspec Biomedical Raman Session - Chair: Nick Stone Selective sampling Raman spectroscopy techniques for ex-vivo intra-operative assessment of surgical margins and lymph nodes in breast cancer surgery FT-CARS flow cytometry or how to measure the Raman spectra of hundreds of cells per second TBD
(21RAM05) Raman Microscopy - Chair: Katsumasa Fujita On self-assembling intracellular Raman reporters and plasmonic nanocavities TBD TBD
(21RAM06) Spatially Offset Raman Spectroscopy - Chairs: Sara Mosca, Fay Nicolson ‘SORS – How Deep?’ Spatially offset femtosecond stimulated Raman microscopy for monitoring real-time exciton diffusion dynamics Facing challenges of Cultural Heritage materials using micro-SORS SESORS detection through bone and tissue Physicochemical analysis of chemicals and biological tissues using spatially offset Raman spectroscopy (21RAM07) Nano-Raman - Chair: TBD Presentations and speakers coming soon. (21RAM08) Industrial Raman - Chair: TBD Presentations and speakers coming soon.
SECURITY AND FORENSIC(21FORENS01) Nuclear Forensics - Chair: Rob Lascola Direct Analysis of Swipe Surfaces for Uranium by a Novel Microextraction-ICP-MS Approach Using a Quadrupole ICP-MS for Isotope Ratio Measurements Matrix-Assisted Ionization Mass Spectrometry for the Detection and Characterization of Uranium Species Laser Ablation Plasma Spectroscopy for Nuclear Material Analysis Exploration of Trace Elements in Pu Using Hand-Held LIBS (21FORENS02) Food Forensics - Chairs: Betsy Jean Yakes, Luis Rodriguez-Saona Rapid Analysis of Declared and Undeclared Anorectic Drugs in Dietary Supplements and Weight-loss Drugs using Surface Enhanced Raman Scattering (SERS) with Handheld Raman Spectrometers Fast, Cheap and Easy: Portable Arsenic Speciation Using Off the Shelf Technology Optimization of Optical Sampling Design for In-line Monitoring of Heterogeneous Foods by NIR Interaction Spectroscopy Determining Food Freshness with Low-cost Electrical Sensing of Water-soluble Gases Portable Optical and Spectroscopic Techniques for Food and Water Contaminants (21FORENS03) Forensic Analysis in the Lab and at the Crime Scene - Chair: Igor Lednev National Institute of Justice: Opportunities for Novel Spectroscopic and Analytical Techniques Applied to Forensic Problems A New Paradigm for Mass Spectral Identifications Trace Detection of THC using Raman Spectroscopy Differentiation Between Hemp-type and Marijuana-type Cannabis Using the Fast Blue BB Color Test Raman spectroscopy to tackle the analysis of bloodstains in crime scene conditions
SPECIAL SESSIONS(21SPECIAL01) Spectrochimica Acta Atomic Spectroscopy Award - Chair: Alessandro De Giacomo Atomic Spectrometry and SAB: Quo Vadis? Gary M. Hieftje The Liquid Sampling-Atmospheric Pressure Glow Discharge: A Combined Atomic and Molecular (CAM) Ionization Source R. Kenneth Marcus 3rd SAB Award: Nanoparticle enhanced laser ablation inductively coupled plasma mass spectrometry Annarosa Mangone 2nd SAB Award: Hyperfine structures and isotopic shifts of uranium transitions using tunable laser spectroscopy of laser ablation plumes Sivanandan S. Harilal 1st SAB Award: About detectability and limits of detection in single particle inductively coupled plasma mass spectrometry Francisco Laborda (21SPECIAL02) Spectroscopy-based Sensors for COVID-19 - Chairs: Jean-Francois Masson, Rob Chimenti Presentations and speakers coming soon. (21SPECIAL03) Remote Teaching Chemistry - Chairs: Christopher Harrison, Chuck Lucy TBD A Resource for Remote and Virtual Learning in Analytical Chemistry – ASDLIB Remote Labs Thomas Spudich Distributed Pharmaceutical Analysis Lab (DPAL) Project TBD (21SPECIAL04) A Session in Honor of Robert (Bob) Hannah - Chair: David Scheering Presentations and speakers coming soon. (21SPECIAL05) A Session in Honor of Peter Griffith 80th Birthday - Chair: Ian Lewis Presentations and speakers coming soon. (21SPSJ01) NIR Spectroscopy - Chair: Christian Huck It is not like we thought. New insights into NIR spectral features of water and hydrated molecules as unveiled by quantum chemical calculations Modern tools of NIR spectroscopy in natural products analysis Water analysis using Near Infrared spectroscopy - Basic research and applications to biology Adding value to speciality foods – the unreasonable roles of NIR spectroscopy Miniature NIR Spectrometers: Possibilities and Pitfalls
SPSJ - SPECTROSCOPICAL SOCIETY OF JAPAN(21SPSJ01) NIR Spectroscopy - Chair: Christian Huck It is not like we thought. New insights into NIR spectral features of water and hydrated molecules as unveiled by quantum chemical calculations. Modern tools of NIR spectroscopy in natural products analysis Water analysis using Near Infrared spectroscopy - Basic research and applications to biology Adding value to specialty foods – the unreasonable roles of NIR spectroscopy Miniature NIR Spectrometers: Possibilities and Pitfalls (21SPSJ02) VUV/FUV Spectroscopy - Chair: Yusuke Morisawa Multielectron-ion coincidence spectroscopy of atoms in intense EUV-FEL fields Cavity enhanced XUV generation at 60 MHz for photoemission spectroscopy. Far- and deep-ultraviolet spectroscopy applied for organic semiconductor/ionic liquids interfaces Study for electronic states of water in high-concentrated aqueous solutions of lithium salts Investigation of electronic structure and transitions of biological molecules by using ATR-FUV spectroscopy (21SPSJ03) DUV Spectroscopy - Chair: Igor Lednev Deep UV Raman for biomedical applications Reinventing reflection objective for high-resolution deep ultraviolet microscopy Stability of nucleic acids in Deep Eutectic Solvents as revealed by Synchrotron UV Resonance Raman spectroscopy Recent advances in instrumentation for deep UV resonance Raman explosive detection DUV Raman spectroscopy for biomedical diagnostics
SURFACE PLASMON RESONANCE(21SPR01) Sensing and Actuating Chemistry - Chair: Amanda Haes Plasmonic Platforms for Polaritonic Chemistry TBD Hybrid Plasmonic Reactors for Photocatalysis and Microbe Inactivation TBD (21SPR02) Plasmonic Sensors - Chair: Emilie Ringe Plasmonic Sensors for Metal Oxide Species SPR Sensors for COVID Antibodies to Measure Seroprevalence, Immunity and Other Ventures Understanding Local Interfacial Properties of Organic/2D Materails Heterostructures via Ultrahigh Vacuum Tip-Enhanced Raman Spectroscopy Right-Handed Twisting Motions of Gold Nanorods Visualized in Live Cell Membranes
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